| 摘要 |
A method of producing an intravenously administrable polyclonal, immunoglobulin preparation, that is not chemically modified, with an IgM proportion of more than 5% by weight, with respect to the total immunoglobulin proportion, and an anti-complementary activity of < 500 CH50/g protein comprising the steps of: (a) Selecting an IgM-containing plasma fraction; (b) Preparing an aqueous solution or suspension from the IgM-containing plasma fraction, the IgM proportion in the aqueous solution or suspension being more than 5% by weight; (c) Incubating the aqueous solution or suspension with a protease to reduce the anti-complementary activity of the aqueous solution or suspension to < 500 CH50/g protein.
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