Transcription regulatory elements such as FGF-inducible response element (FiRE) associated with syndecan-1 gene

摘要

A purified DNA molecule consisting of a syndecan enhancer element, wherein the syndecan enhancer element are inducible by FGF-2 (fibroblast growth factors-2), FGF-7, EGF and/or TGFa factors. The polypeptides derived are capable of activating the enhancer element which is linked to a structural gene, and the use may regulate the expression of syndecan-1 genes. The enhancer element can also be used to target expression of a gene to repair wound sites.