Use of herpes simplex virus glycoprotein d variants

摘要

A method for inhibiting the infection of susceptible non-human cells by herpes simplex virus is described. The method involves contacting the cells with a composition that comprises an acceptable carrier and a variant molecule selected from the following: (a) a variant herpes simplex virus glycoprotein D molecule comprising amino acids 1-300 of SEQ ID NO:2 (as defined in the specification), (b) the variant molecule of (a) further comprising amino acids -2 and -1 of SEQ ID NO:2, (c) the variant molecule of (a) further comprising amino acids 301-306 of SEQ ID NO:2 and (d) a gD-1(?290-299t) molecule comprising amino acids -2 to306 of SEQ ID NO:2.