| 摘要 |
<p>Process for the preparation of the cyclic pentapeptidecyclo(Arg-Gly-Asp-DPhe-NMeVal)by cyclization of a linear pentapeptide selected from the group consisting ofH-Arg(Pbf)-Gly-Asp(OBzl)-DPhe-NMeVal-OH,H-Gly-Asp(OBzl)-DPhe-NMeVal-Arg(Pbf)-OH,H-Asp(OBzl)-DPhe-NMeVal-Arg(Pbf)-Gly-OH,H-DPhe-NMeVal-Arg(Pbf)-Gly-Asp(OBzl)-OH orH-NMeVal-Arg(Pbf)-Gly-Asp (OBzl)-DPhe-OH,subsequent protective group removal and, if appropriate, further conversion into its physiologically acceptable salts.</p> |
