| 摘要 |
The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing said peptide and related impurities, and to an industrial method including such ion exchange chromatography process. The elution step is performed with a solution comprising an organic modifier, e.g. alcohols, alkanoic acids, urea, guanidine, polyalcohols etc. The aqueous elution medium supports a net charge distribution on the protein or peptide that differs from the net charge of the impurities. |
