发明名称 |
USE OF PIRENOXINE FOR THE PROTECTION OF CORNEAL TISSUES IN PHOTOKERATECTOMY |
摘要 |
Pirenoxine or 1-hydroxy-5-oxo-5H-pyrido-[3,2a]-phenoxazin-3-carboxylic acid, also called pirfenossone and already used as anti-cataract agent, in the form of a pharmaceutically acceptable salt thereof, if desired, is used for the protection of the corneal tissue in photokeratectomy interventions, as cornea photoablation using excimer laser, for both refractive and therapeutic purpose. In fact pirenoxine is able to inhibit, in the cornea, the oxidative phenomena determined by reactive oxygen species (ROS) which are produced within the tissues following the laser irradiation.
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申请公布号 |
WO0054757(A2) |
申请公布日期 |
2000.09.21 |
申请号 |
WO2000IT00081 |
申请日期 |
2000.03.13 |
申请人 |
FARMIGEA S.P.A.;BOLDRINI, ENRICO;CIUFFI, MARIO |
发明人 |
BOLDRINI, ENRICO;CIUFFI, MARIO |
分类号 |
C07D498/04;A61F9/007;A61K31/496;A61K31/5383;A61P27/02;A61P41/00;(IPC1-7):A61K31/00 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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