| 摘要 |
medicine. SUBSTANCE: method involves studying pregnant women hemostasis system at the second and the third trimester of gestation period within the framework of monitoring research. Thrombin time and fibrinogen concentration are used as significant information signs of hemostasiogram during the second trimester. Pattern recognition techniques are applied for determining F value assumed by function defined by a formula F=0.96A- 0.024B-2.51, where A is the fibrinogen concentration in g/l, B is the thrombin time in s. The value of F being greater than 0.31, postpartum hemorrhage is predicted. The value of F being less than -0.27, pathologic blood losses are predicted during the labor. Fibrinogen concentration beta in plasma and the level of D dimers, blood platelets number and thromboelastogram parameter K obtained under conditions of high contact activation of hemocoagulation, are used as significant information indices of hemostasiogram during the third trimester. Pattern recognition techniques are applied for determining P value of function defined by a formula P=-0.89C-0.59D-0.014E+0.012G-1.14, where C is the fibrinogen beta concentration in plasma in g/l, D is the level of D dimers in ng/ml, E is the blood platelets number 109/ml, G is the K parameter in mm. The value of P being greater than 0.2, postpartum hemorrhage is predicted. The value of P being less than -0.2, pathologic blood losses are predicted during the labor. The value of F being within the limits of -0.27 to 0.31 and P being within the limits of -0.2 to 0.2, uncertain prognosis zone is considered to be the case. EFFECT: enhanced reliability in selecting hemorrhage complications development risk groups.
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