Recombinant herpes simplex viruses vaccines and methods

摘要

A recombinant herpes simplex virus genome having modified gamma 134.5 genes incapable of expressing an active ICP34.5 gene product, vaccines comprising the recombinant herpes simplex virus genome methods for immunizing a host against the herpes simplex virus using the recombinant herpes simplex virus genome, and a method for preparing the vaccine are disclosed.