LUBRICANT AND SOLID PREPARATION USING THE SAME

摘要

PROBLEM TO BE SOLVED: To obtain a lubricant which can remarkably improve the uniformity of medicine contents among solid preparations by specifying the average particle diameter of fatty acid metal salt particles as the lubricant and the content of the large fatty acid metal salt particles. SOLUTION: This lubricant comprises fatty acid metal salt (for example, calcium stearate) particles which have an average particle diameter of <=4μm and contains the particles having particle diameters of >10μm in an amount of <=4 wt.% based on the total amount of the fatty acid metal salt particles. The fatty acid metal salt particles preferably have a difference RC-RA of <=3μm between 30% particle diameter RA (exhibits that 30% of the fatty acid metal salt particles on the basis of the total amount of the fatty acid metal salt particles have smaller particle diameters than RA) and 70% particle diameter RC or a difference RD-RB of <=6μm between 50% particle diameter RB and 95% particle diameter RD. When the lubricant is used for preparing solid preparations by a compression-molding method, the obtained solid preparations have the remarkably improved uniformity of medicine contents.