| 摘要 |
A process for isolating enantiomer components from a mixture of enantiomers through co-crystallization is disclosed, comprising the steps of (a) forming a solution comprising the mixture of enantiomers (R) and (S) and co-crystallization agents C1 and C2, wherein C1 and C2 are chiral or achiral, with the proviso that at least one of C1 and C2 is chiral and C1 and C2 do not form an enantiomeric pair, whereby C1 forms a co-crystal with (R) and C2 forms a co-crystal with (S); (b) super-saturating the solution in C1.(R) and C2.(S); (c) inducing crystallization of co-crystals of C1.(R) and C2.(S); and (d) isolating the C1.(R) co-crystals and C2.(S) co-crystals.
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