| 摘要 |
The present invention relates to 4-aminoquinolines and derivatives thereof. More particularly the present invention relates to 4-aminoquinolines and derivatives thereof for use in the treatment and prophylaxes of malaria. The compounds are compounds of Formula (IV) where: W is C1 or CF3; X is N or N=O; R is selected from: i) R2-NH-R1-Z-where: Z is NH, S, O or CH2; R1 is a C1 to C4 alkyl group; and R2-NH- is a group resistant to dealkylation in vivo; or ii) (a) where: Z and R1 are as described in (i) above, and (b) is a group resistant to dealkylation in vivo; or, iii) R4-Ar-Z- where: Z is as described in (i) above; Ar is a substituted or unsubstitued aromatic ring structure; and R4 is a planar or non planar, alkyl or cycloalkyl substituent on the 5' position of the aromatic ring Ar. |
