CARBAMOYL TETRAHYDROPYRIDINE DERIVATIVES

摘要

Carbamoyl tetrahydropyridine derivatives represented by general formula (1) and being efficacious against CRF-related diseases; medicinally acceptable salts of the same; and intermediates for the preparation thereof, wherein R<1> and R<2> are each independently hydrogen, C1-C5 alkyl, or the like; Y<1>-Y<2> is (R<4>)C=C(R<5>), (R<6>)C=N, N=N, (R<7>)N-CO, or N=C(R<8>); X<1>, X<2> and X<3> are each independently hydrogen, halogeno, or the like; R<3>, R<4>, R<5> and R<6> are each independently hydrogen or alkyl; R<7> is hydrogen, C1-C5 alkyl, or the like; and R<8> is hydrogen or carbamoyl.