| 摘要 |
chemistry of proteins, hormones. SUBSTANCE: invention relates to acylation of proteins and can be used in chemical and medicinal industry. Invention describes a single-step method of selective acylation of epsi-aminogroup of proinsulin, insulin or insulin analog in the presence of free alpha-aminogroup using soluble activated fatty acid ester in polar solvent at pH 9.5-11.5. EFFECT: simplified technology of insulin derivatives producing, high yield of end product. 5 cl, 2 tbl, 9 ex |
