| 摘要 |
<p>The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R?0 and R1¿ are independently selected from H, halogen, C¿1-6?alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms; R?2¿ is halogen, CN, CONR4R5, CO2H, CO2C1-6alkyl, or NHSO2R4; R3 is C¿1-6?alkyl or NH2; and R?4 and R5¿ are independently selected from H, C¿1-6?alkyl, phenyl, phenyl substituted by one or more atoms or groups (selected from halogen, C1-6alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms), or together with the nitrogen atom to which they are attached form a saturated 4 to 8 membered ring. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.</p> |
