| 摘要 |
<p>The invention relates to the use of succinic acid or pharmaceutically acceptable salts thereof for manufacture of medicaments or nutritional supplements effective for treating of insulin resistance in mammals, preferably in a non-insulin dependent diabetic humans. Insulin resistance is associated with disorders such as diabetes mellitus and its chronic complications such as retinopathy, polyneuropathy, nephrophathy, angiopathy, gestational diabetes mellitus; impaired glucose tolerance; obesity; aging; atherosclerosis; syndrome X; cardiovascular disease; AIDS; cancer; wasting/cachecxia; sepsis; trauma associated with burns; malnutrition; lupus and other autoimmune diseases; endocrine diseases; hyperuricemia; hyperlipidemia; dyslipidemia; polycystic ovary syndrome or complications arising from athletic activity. The invention provides a method of treating insulin resistance in mammals, preferably, in humans, which comprises administering to a mammal in need thereof succinic acid or pharmaceutically acceptable salts thereof.</p> |
