| 摘要 |
<p>This invention is a method, and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage, and a long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode (100) having a "keying" element that determines the set point of the therapy voltage pulse, and/or selected array switching patterns. A number of electrode applicator designs (100) permit access to, and treatment of a variety of tissue sites. A disposable needle tip array (100) may be implemented.</p> |
