发明名称 |
Process for producing 6-amino-penicillanic acid and phenylacetic acid |
摘要 |
PCT No. PCT/ES97/00066 Sec. 371 Date Feb. 25, 1998 Sec. 102(e) Date Feb. 25, 1998 PCT Filed Mar. 14, 1997 PCT Pub. No. WO97/35029 PCT Pub. Date Sep. 25, 1997Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate penicillin salt as a solid by a process of ultrafiltration of the culture broth in at least 2 successive stages. The first stage has a cut-off for molecular weights of 20,000 Dalton and the second, 2000 Dalton. Subsequent to the enzyme conversion stage the products from that stage are subjected to a series of anionic exchange chromatography steps.
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申请公布号 |
US6110699(A) |
申请公布日期 |
2000.08.29 |
申请号 |
US19980952311 |
申请日期 |
1998.02.25 |
申请人 |
ANTIBIOTICOS, S.A. |
发明人 |
OLIVER RUIZ, MANUEL;FRAILE YECORA, NIEVES;GONZALEZ DE PRADO, EMILIANO;VITALLER ALBA, ALEJANDRO;SALTO MALDONADO, FRANCISCO |
分类号 |
B01D61/14;C07D499/10;C07D499/12;C07D499/18;C07D499/42;C12P37/06;(IPC1-7):C12P37/00 |
主分类号 |
B01D61/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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