New 3-(phenoxy or phenylalkoxy)-2-phenyl-propylamines, useful for treating e.g. arrhythmia, spasms, pain or neurodegenerative diseases, are tension-dependent sodium channel blockers

摘要

3-(Phenoxy or phenylalkoxy)-2-phenyl-propylamines (I) are new. Phenylpropylamine derivatives of formula (I) (including optical isomers, enantiomer mixtures, racemates, free bases and acid addition salts) are new. R1, R2 = H, 1-8C alkyl, benzyl, furylmethyl, cycloalkyl, cycloalkylmethyl, 2-8C alkenyl (preferably allyl), 2-8C alkynyl (preferably propargyl), (1-8C) alkoxy-(CH2)l or (3-8C) cycloalkoxy-(CH2)m; or NR1R2 = 3-8 membered heterocycle (optionally substituted by 1-4 methyl or one CH2CH2); or R1 + R2 = CH2CH=CHCH2CH2; l = 1-8; m = 0-8; n = 0-3; R3, R'3, R4, R'4 = H, F, Cl, Br, OH, Me, Et or OMe; Me = methyl; Et = ethyl; R5, R6 = H, F, Cl, Br, Me or Et; R7 = H, F, Cl or Me; or forms a fused benzene ring with the vicinal position; R8 = H, F, Cl or Me. Independent claims are included for the preparation of (I).