| 摘要 |
PCT No. PCT/IT96/00149 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Jul. 24, 1996 PCT Pub. No. WO97/05193 PCT Pub. Date Feb. 13, 1997A process of surface activation of a material based on one or more of the copolymers of lactic acid and epsilon -caprolactone is carried out on bioabsorbable and biocompatible aliphatic polyesters chosen from the group formed by homo- and copolymers derived from L-lactide, D-lactide, racemic D,L-lactide, meso D,L Lactide, epsilon -caprolactone, glycolide, delta -valerolactone, p-dioxanone, preferably copolymers of L-lactide, D-lactide, racemic D,L lactide, meso D,L-lactide with epsilon -caprolactone; the process consists of performing at least one of the following treatments: acid or base hydrolysis, treatment by means of cold plasma, by chemical reactions or electromagnetic radiations. The process brings about a substantial increase in surface hydrophilicity and, consequently, a significant lowering of the wetting angle measured with water at 23 degrees Celsius in air. This can in many cases favor cellular adherence to bioabsorbable medical prostheses realized using these materials, and thus surface-activated, such as for example endothelialisation processes in vascular grafts.
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