发明名称 |
Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition |
摘要 |
A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described. Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF. |
申请公布号 |
SE513358(C2) |
申请公布日期 |
2000.08.21 |
申请号 |
SE19910002079 |
申请日期 |
1991.07.03 |
申请人 |
AMGEN INC |
发明人 |
FRANKLIN D *COLLINS;DRZISLAV *MISMER;LEU-FIN *LIN;CHRISTINE *KO |
分类号 |
C12N15/09;A61K35/30;A61K38/00;A61K38/22;A61P25/00;A61P25/28;C07K1/14;C07K1/20;C07K14/435;C07K14/475;C07K14/48;C07K14/52;C07K16/22;C12N1/21;C12N5/10;C12N15/06;C12N15/12;C12N15/18;C12N15/31;C12N15/74;C12P21/00;C12P21/02;C12R1/19;C12R1/91;(IPC1-7):C07K14/475;A61K38/18 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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