| 摘要 |
<p>Cyclic peptides containing as constituting strand(s) one or two amino acid sequences selected from among amino acid sequences Glu-Ala-Asp-Asp-Arg and Ser-Gln-Lys-Glu-Gly; and AIDS vaccines containing these cyclic peptides as the active ingredient. Preferably, a cyclic dodecapeptide represented by formula (I) and an AIDS vaccine containing this peptide as the active ingredient. From the viewpoints of absorption in vivo and antibody expression, it is desirable that active groups selected from carboxyl, amino and hydroxyl groups contained in these peptides are attached to substituents. The above cyclic dodecapeptide can neutralize the second receptor in the infection of human beings with HIV-1 virus.</p> |
