G-PROTEIN COUPLED HEPTAHELICAL RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF

摘要

G-protein coupled heptahelical binding compounds are described, e.g. compounds of the formula (I): J-M wherein J is an aromatic moiety and M is a G-protein coupled heptahelical receptor pocket interacting moiety. The compounds of the invention can be used to treat chemokine mediated disorders, e.g. neurological, immunological, inflammatory and cancer related disorders.