| 摘要 |
PCT No. PCT/US93/09895 Sec. 371 Date Apr. 14, 1995 Sec. 102(e) Date Apr. 14, 1995 PCT Filed Oct. 14, 1993 PCT Pub. No. WO94/08601 PCT Pub. Date Apr. 28, 1994B cell lymphoma tumor-associated antigen or a fragment thereof containing an epitope are linked to an immune-enhancing cytokine, such as GM-CSF, IL-2, or IL-4 to form an immuno-complex. This immuno-complex elicits immune responses which are protective with respect to tumor proliferation. The linkers may be simple chemical bifunctional moieties introduced through chemical synthetic techniques or peptides introduce through recombinant methodologies. Antibodies immunoreactive with these immunocomplexes are also useful as passive vaccines and as analytical tools.
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