| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new thienopyridine derivative having low toxicity, an excellent gonadotropin releasing hormone-antagonizing action, good oral absorbability, excellent stability, and excellent medicine disposition, and useful as a sexual hormone-dependent cancer medicine, an infertility therapeutic medicine, a menses-controlling medicines, etc. SOLUTION: A compound of formula I [R1 is a (substituted) 1-7C alkyl, a (substituted) 3-7C cycloalkyl, a (substituted) 1-6C alkoxyamino or a (substituted) hydroxyamino; and R2 is a (substituted) 1-7C alkyl or a (substituted) phenyl, provided that when R1 is a non-substituted alkyl, R2 is a substituted 1-7C alkyl or a substituted phenyl]. For example, 3-(N-benzyl-N- methylaminomethyl)-4,7-dihydro-5-isobutyryl-7-(2,6-difluorobenzyl)-2-( 4-cyclopropane carbonylaminophenyl)-4-oxothieno[2,3-b]pyridine (salt). The compound of formula I is obtained, for example, by reacting a compound of formula II with a compound of the formula: R1aCOOH [R1a is a (substituted) 1-7C alkyl or the like]. |
