| 摘要 |
PROBLEM TO BE SOLVED: To provide a crystal polymorphism of 2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4- hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetic acid dihydrate having strongβ2-adrenergic receptor stimulation action andβ3-adrenergic receptor stimulation action and useful e.g. as a pain remission agent and a lithagogue for lithangiuria. SOLUTION: This crystal polymorphism gives a powder X-ray diffraction pattern having strong diffraction peaks at the diffraction angles (2θ+0.1) of 3.4, 10.2, 13.7, 17.1 and 20.7 deg.. It can be produced by dissolving 2-[4-[2-[[(1S,2R)-2- hydroxy-2-(4hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy] acetic acid in a mixture of water and methanol (at a volume ratio of 1:3 to 1:4), concentrating under reduced pressure and drying the precipitated crystal under reduced pressure at room temperature to 40 deg.C for several hours.
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