摘要 |
PROBLEM TO BE SOLVED: To obtain an optically active α-alkyl benzyl alcohol useful as an intermediate for medicament and agrochemicals by the asymmetric reduction of a specific phenyl alkyl ketone with a hydrogen donor in the presence of a specific combinatorial catalyst. SOLUTION: By the asymmetric reduction of a phenyl alkyl ketone (preferably m-trifluoromethylacetophenone) of formula I [wherein, R1 is H, a halogen or a (halo)alkyl; (n) is -5; R2 is an alkyl or a cycloalkyl] with a hydrogen donor in the presence of a combinatorial catalyst between a group IX transition metal compound [preferably dirhodium (III) di-μ-chlorodichlorobis(pentamethylcyclopentadienyl)], having a (substituted) cyclopentadienyl group and an optically active cyclohexanediamine compound (preferably N-tosyl-1,2- cyclohexanediamine) of formula II [wherein, R3 is a lower alkyl or a (substituted) phenyl], the objective compound of formula III (wherein, * shows asymmetric carbon) is obtained. |