2-aminopropane-1,3-diol compounds and medicinal use thereof

摘要

These compounds, which are useful as preventives or depressants for rejection reactions in organ or bone marrow transplantations and preventives or remedies for various autoimmune diseases, various allergic diseases are represented by general formula (I), pharmaceutically acceptable acid addition salts thereof, or hydrates of the same where R1, R2, R3 and R4 represent each hydrogen or acyl Also included is 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl) phenyl)ethyl)propane-1,3-diol and 2-amino-2-(2-(4-formylphenyl)ethyl)-propane-1,3-diol optionally protected at the amino and/or hydroxy group or salts thereof, which are useful as intermediates in synthesizing the above compounds