| 发明名称 |
REDUCTIVE ALKYLATION OF SECONDARY AMINES WITH HYDROSILANE |
| 摘要 |
A novel process for the production of tertiary amines by reductive alkylation of second amine using hydrosilane and a Lewis acid is disclosed. The novel process has application in the preparationof imidazole-containing benzodiazepines, inhibitors of farnesyl protein transferase.
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| 申请公布号 |
WO0041992(A1) |
申请公布日期 |
2000.07.20 |
| 申请号 |
WO1999US30299 |
申请日期 |
1999.12.20 |
| 申请人 |
BRISTOL-MYERS SQUIBB CO. |
发明人 |
CHEN, BANG-CHI;SUNDEEN, JOSEPH, E.;GUO, PENG |
| 分类号 |
A61K31/5513;A61P35/00;A61P43/00;C07C209/28;C07D243/14;C07D403/06;C07D409/12;C07D409/14;(IPC1-7):C07C209/28;C07D233/34;C07D333/64 |
主分类号 |
A61K31/5513 |
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