GENE THERAPY TO PROMOTE ANGIOGENESIS

摘要

Angiogenesis is a complex biological phenomenon. Various signals and compoun ds have been shown to influence angiogenesis in vivo. Patients suffering from endothelial dysfunction often produce substantial amounts of the angiogenic factors such as bFGF and VEGF but still novel angiogenesis in these patients is not observed or insufficient. In the present invention it has been found that nitric oxide is capable of enhancing angiogenesis in endothelial dysfuncion. The present invention provides a nulceic acid delivery vehicle f or enhancing and/or inducing angiogenesis, comprising a nucleic acid comprising at least one sequence coding for a protein capable of increasing nitric oxid e production, and further comprising a nucleic delivery carrier.