METASTASIS MODELS USING GREEN FLUORESCENT PROTEIN (GFP) AS A MARKER

摘要

A method to follow the progression of metastasis of a primary tumor, which method comprises observing fluorescence at various locations in an intact animal model is described. Animals which contain GFP producing tumors are useful models to study the mechanism of metastasis, as well as to evaluate candidate protocols and drugs. In addition, subjects already harboring tumors can be treated so as to modify the endogenous tumours to contain GFP, to permit clinical applications.