| 摘要 |
In the present invention there is disclosed a process for preparing pharmaceutically acceptable salts of naphthyridone carboxylic acid of the general formula I in which Re1H represents a pharmaceutically acceptable acid being selected from a group comprising acids of the general formula {Re4SOi3H}, {Re4POi3H} and YH, wherein Re4 represents an alkyl group containing 1 to 6 carbon atoms or an optionally substituted phenyl group or a naphthyl group, whereby the substituent is an alkyl group containing 1 to 6 carbon atoms and Y represents the group Cl, {SOi4}, {HSOi4}, {NOi3}, {HPOi3H} or {POi4}. The preparation process is characterized in that the compound of the general formula II, in which Re2 represents an alkyl group containing 1 to 6 carbon atoms, and arylalkyl group containing 1 to 6 carbon atoms in the alkyl moiety or a hydrogen atom and Re3 represents the group of the formula {NOi2} or {NHi2} is brought into reaction (a) with the compound of the general formula Re1H wherein Re1H is as specified above provided the substituent Re3 represents the group of the general formula {NHi2} or (b) with a reducing agent in the presence of the compound of the general formula Re1H wherein Re1H is as specified above provided the substituent Re3 represents the group of the general formula {NOi2}. In the present invention there are also claimed intermediates of the general formulae II and IV for preparing the compound of the general formula I.
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