| 发明名称 |
CHEMICAL COMPOUNDS |
| 摘要 |
This invention relates to compounds of formula (1), wherein substituents are defined in the description, that inhibit farnesylation of mutant ras gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation of ras. |
| 申请公布号 |
WO0039716(A2) |
申请公布日期 |
2000.07.06 |
| 申请号 |
WO1999GB04308 |
申请日期 |
1999.12.17 |
| 申请人 |
ASTRAZENECA UK LIMITED;ZENECA-PHARMA S.A.;ARNOULD, JEAN-CLAUDE;OLIVIER, ANNIE, ANTOINETTE, CHRISTIANE |
发明人 |
ARNOULD, JEAN-CLAUDE;OLIVIER, ANNIE, ANTOINETTE, CHRISTIANE |
| 分类号 |
C07D233/58;A61K31/415;A61K31/4164;A61K31/4178;A61K31/454;A61K31/5377;A61P35/00;A61P43/00;C07D233/54;C07D233/61;C07D233/64;C07D409/06;C07D409/10;C07D409/12;C07D409/14;C07D521/00 |
主分类号 |
C07D233/58 |
| 代理机构 |
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代理人 |
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