METHOD FOR MANUFACTURING TAXOL USING YEW TREE

摘要

PURPOSE: A method for manufacturing taxol of formula (1) is provided which accumulates high concentration of taxol in the culture broth by culturing Pestalotia heterocornis in the medium including the powder or the extract of yew tree. CONSTITUTION: A taxol-producing bacteria such as Pestalotia heterocornis KCTC 0340BP are cultured in the medium including the powder or the extract of yew tree during the production of taxol. The production of taxol is increased from 30 μg to 3.7 mg based on 1 liter of medium by adding 0.5-100 g of yew tree into 1 liter of media. Any parts of yew tree such as root, stem, leaf, and so forth are available. The extract of yew tree is obtained by the extraction at 30-70°C for 1- 10 hours using methanol.