发明名称 |
Non-peptide antagonists of glp-1 receptor and methods of use |
摘要 |
Non-peptide compounds that act as antagonists of the intestinal hormone glucagons-like peptide 1 (GLP-1) have a 9H-b-carboline central motif. The compounds exhibit advantageous physical, chemical and biological properties and inhibit GLP-1 peptide binding to the GLP-1 receptor and/or prevent activation of the receptor by bound GLP-1. The invention further relates to a method of inhibiting the binding of GLP-1 to the GLP-1 receptor and a method of inhibiting the activation of the GLP-1 receptor. Intermediate compounds useful for making non-peptide GLP-1 receptor antagonists are also described. |
申请公布号 |
AU1751800(A) |
申请公布日期 |
2000.06.26 |
申请号 |
AU20000017518 |
申请日期 |
1999.12.08 |
申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
LARRY KENNETH TRUESDALE;RICHARD A. BYCHOWSKI;JAVIER GONZALEZ;ATSUO KUKI;RANJAN JAGATH RAJAPAKSE;MIN TENG;DAN KIEL;DALJIT S. DHANOA;YUFENG HONG;TSO-SHENG CHOU;ANTHONY L. LING;MICHAEL DAVID JOHNSON;VLAD EDWARD GREGOR |
分类号 |
C07D491/147;A61K31/437;A61K31/519;A61P5/48;A61P43/00;C07D471/04;C07D471/10;C07D471/14;C07D491/04;C07D491/14;C07D521/00 |
主分类号 |
C07D491/147 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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