| 摘要 |
PURPOSE: GABAB receptor agonists for the inhibition of transient lower esophageal sphincter relaxations, and for the treatment of gastro-esophageal reflux disease is provided. CONSTITUTION: Preferred form of GABAB receptor agonist is a substituted amino propyl acid derivative where the acidic head is a carbolic group, a phosphinic group, a phosphonous group or a sulfinic group, 4-amino-3-(4-chlorophenyl)butanoic acid (baclofen), (3-amino-2-hydroxypropyl)methylphosphinic acid, 4-aminobutanoic acid (GABA), (3-amino-2-(4-chlorophenyl)propyl)sulfinic acid, (3-amino propyl)(difluoromethyl)phosphinic acid, (3-amino-2-oxo-propyl)metyl phosphinic acid, 4-amino-3-(5-chlorothien-2-yl)butanoic acid, (3-amino propyl)phosphonous acid, etc.
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