发明名称 |
METHODS FOR ENHANCING GRAFT SURVIVAL BY MODULATING HEME OXYGENASE ACTIVITY |
摘要 |
Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein. Nucleic acid molecules that modulate heme oxygenase-I activity and therefore find use in the described methods include, for example, molecules that encode a polypeptide that itself exhibits heme oxygenase-I activity or antisense oligonucleotides that act to inhibit heme oxygenase-I activity in a cell.
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申请公布号 |
WO0036113(A2) |
申请公布日期 |
2000.06.22 |
申请号 |
WO1999US30089 |
申请日期 |
1999.12.17 |
申请人 |
SANGSTAT MEDICAL CORPORATION;BUELOW, ROLAND;WOO, JACKY;IYER, SUHASINI |
发明人 |
BUELOW, ROLAND;WOO, JACKY;IYER, SUHASINI |
分类号 |
C12N15/09;A61K9/127;A61K31/7088;A61K48/00;A61P37/06;A61P43/00;C12N5/02;C12N9/02;C12N15/53;(IPC1-7):C12N15/53;C12N15/63;C12N15/85;C12N15/861;C12N15/87;C12N15/88 |
主分类号 |
C12N15/09 |
代理机构 |
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主权项 |
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地址 |
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