发明名称 |
PROCESS FOR THE PREPARATION OF 3-CEPHEM COMPOUNDS |
摘要 |
<p>A process for preparing a 3-cephem compound represented by the formula (3), the process comprising the steps of reacting a beta -lactam compound represented by the formula (1) with a phosphorus halide compound in the presence of an organic base to give an imino- beta -lactam compound represented by the formula (2), adding a phenol to the same reaction system to cause decomposition due to reaction with an alcohol and simultaneously to remove the protection of carboxylic acid ester, giving a 3-cephem compound represented by the formula (3) or a salt thereof <CHEM> <CHEM> wherein R1, R2 R3 and X are as defined above.</p> |
申请公布号 |
EP1010701(A1) |
申请公布日期 |
2000.06.21 |
申请号 |
EP19990926869 |
申请日期 |
1999.06.30 |
申请人 |
OTSUKA KAGAKU KABUSHIKI KAISHA |
发明人 |
KAMEYAMA, YUTAKA;YAMADA, TAKAE;SUH, DAL SOO |
分类号 |
C07D501/04;A61K31/545;A61K31/546;A61P31/04;C07D501/00;C07D501/18;(IPC1-7):C07D501/04 |
主分类号 |
C07D501/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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