| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel 3-indolylpiperidines of the formula (I) where R1, R2, R3, R4 mean H, A, OH, OA, F, Cl, Br, J, CN, CF3, COOH, CONH2, CONHA, CONA2 or COOA; or R1 and R2 and also R3 and R4 in common mean methylenedihydroxy-group; R5 is H or OH; R6 is H or R5 and R6 in common mean a bond; A means C1-C6-alkyl; n is the whole number from 2 to 6, and their physiologically acceptable salts. Compounds of the formula (I) show effect on central nervous system, especially they show serotonin-agonistic or serotonin-antagonistic effect. EFFECT: improved method of synthesis, valuable pharmacological properties. 5 cl, 2 tbl, 12 ex |
