A mammal with inducible in situ ductal carcinoma useful as a model for research and identification of therapeutics

摘要

A mammal with an inducible in situ ductal carcinoma (DCIS), where the mammal contains an oncogene activatible through a lactotropic hormone, is new. An Independent claim is also included for a method for preparing a mammal as above comprising: (a) introducing a DNA coding for an oncogene in fertilized oocytes of a mammal, where the DNA under the control of a promoter is specific for a lactotropic hormone; (b) implantation of the oocyte in a pseudopregnant mammal; and (c) selection of progeny of containing the DCIS.