| 摘要 |
PURPOSE: New manufacturing method of 4-hydroxy-£1,2,3,4-tetrahydro-3-{4-(4-trifluoromethyl-benzyloxy)phenyl}-1-naphtyl|thiocoumarin is provided which is carried out under mild condition and obtains the highly pure target compound in high yields. CONSTITUTION: Tetraol derivative is reacted with 4-hydroxythiocoumarin at about 100-110°C for 1-5 hrs concurrently with reflux. Thiocoumarin is prepared by the conventional methods of extracting, drying, filtering or removing the solvent after the reaction. The alkoxy group of the thiocoumarin is hydrolyzed by having a reflux with hydrogen halide for 5-10 hours to produce 4-hydroxy-£1,2,3,4-tetrahydro-3-S(4-hydroxyphenyl)-1-naphtyl|thiocoumarin under the conventional hydrolyzing condition of ester. The thiocoumarin compound reacts with trifluoromethylbenzen halide in the presence of alkoxide to produce 4-hydroxy-£1,2,3,4-tetrahydro-3-{4-(4-trifluoromethyl-benzyloxy)phenyl}-1-naphtyl|thiocoumarin(1)
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