PROTEIN TRANSDUCTION SYSTEM AND METHODS OF USE THEREOF

摘要

The present invention provides a protein transduction system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically activated in a cell exhibiting a unique characteristic. Further provided are protein transduction domains tha t provide enhanced transduction efficiency. The protein transduction system effectively kills or injures cells infected by one or a combination of different pathogens or cells exhibiting unique characteristics such as high levels of heavy metals, DNA damage or uncontrolled cell division.