THERAPEUTIC AGENT FOR PARKINSON'S DISEASE

摘要

Disclosed are therapeutic agents for Parkinson's disease containing as an active ingredient a xanthine derivative or a pharmaceutically acceptable salt of the xanthine derivative, the xanthine derivative being represented by the following Formula (I): (see formula I) in which R1 and R2 represent independently methyl or ethyl; R3 represents independently hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; R4 represents cycloalkyl, -(CH2)n-R5 (in which R5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4), or (see formula II) (in which Y1 and Y2 represent independently hydrogen, halogen, or lower alkyl; and Z represents substituted or unsubstituted aryl, (see formula III) (in which R6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m represents an integer of 1 to 4), or a substituted or unsubstituted heterocyclic group); and X1 and X2 represent independently O or S. Disclosed is also a xanthine derivative represented by the following Formula (I-A): (see formula IV) in which R3a represents hydrogen or lower alkyl; Z a represents (see formula V) (in which at least one of R7, R8, and R9 represents lower alkyl or lower alkoxy and the others represent hydrogen; R10 represents hydrogen or lower alkyl) or (see formula VI) (in which R6 and m have the same meanings as defined above); and R1 and R2 have the same meanings as defined above, and a phamaceutically acceptable salt thereof.