| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject inhibitor having an inhibitory action on transformation growth factorβ, useful for treating chronic glomerular nephritis, renal interstitial fibrosis, diabetic nephropathy, hepatocirrhosis, etc., by making the inhibitor include ursolic acid (salt) as an active ingredient. SOLUTION: This inhibitor contains ursolic acid (salt) of the formula as an active ingredient. Ursolic acid is contained in leaves and fruits of persimmon, Crataegus cuneata, apple, etc., can be obtained from these plants by extraction/ separation and purification and is sold on the market. An alkaline (earth) metal salt, an organic basic salt including a basic amino acid salt, etc., may be cited as the ursolate. When the inhibitor is used as medicine, a dose as ursolic acid is preferably about 0.01-1,000 mg and administered dividedly twice or three times daily in the case of adult. The inhibitor can be used as an oral medicine such as tablet, syrup, etc., and as an external preparation such as ointment, etc., or an injection, etc.
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