发明名称 |
Method for the preparation of pearls and pearls obtained containing an active ingredient with an undefined crystallization point |
摘要 |
Pearls of an active principle exhibiting an indefinite crystallization point, wherein said pearls exhibit a prolonged, immediate or combination release profiles, are made by melting the active principle and a crystallization excipient to create a molten mixture; introducing the mixture into feed receptacles of a prilling tower; passing the mixture through a nozzle which is vibrated to form pearls; and allowing the pearls to fall in the tower countercurrentwise to cold air, where the tower is provided with a fluidized bed proximate the bottom of the tower and the temperature conditions of the said fluidized bed are maintained depending on the release profile desired.
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申请公布号 |
US6074580(A) |
申请公布日期 |
2000.06.13 |
申请号 |
US19960760155 |
申请日期 |
1996.12.03 |
申请人 |
AVENTIS PHARMA SA |
发明人 |
LE THIESSE, JEAN-CLAUDE;DELEUIL, MICHEL |
分类号 |
A61J3/06;A61K9/16;B01J2/04;(IPC1-7):B29B9/00 |
主分类号 |
A61J3/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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