发明名称 |
Heteroarylthio compounds and cancer remedies containing the same |
摘要 |
Compounds represented by the following general formula (I) Ar<1>-S-R<1>-S-Ar<2>, and salts thereof, which have an effect of inhibiting ribonucleotide reductase to suppress the proliferation of cancer cells selectively wherein Ar<1> is aryl bearing 1 to 3 hydroxyl groups on the ring; Ar<2> is monocyclic heteroaryl containing as the ring-constituting atoms 1 to 3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur and optionally bearing a substituent on the ring; and R<1> is -R<2>-X<1>-R<3>- [wherein R<2> and R<3> are each independently an optionally substituted C1-C10 carbon chain; and X<1> is CH2, O or N(R<4>) (wherein R<4> is a monovalent group or a monovalent atom)]. |
申请公布号 |
AU1182400(A) |
申请公布日期 |
2000.06.05 |
申请号 |
AU20000011824 |
申请日期 |
1999.11.17 |
申请人 |
KYOWA HAKKO KOGYO CO. LTD.;FUJI PHOTO FILM CO. LTD. |
发明人 |
TATSUYA TAMAOKI;TAKESHI TAKAHASHI;TAMIO MIZUKAMI;YUKO KANDA;MASAYUKI KAWAKAMI;KAZUNOBU TAKAHASHI;YONGZHE YAN |
分类号 |
A61P35/00;C07D207/12;C07D233/84;C07D249/12;C07D277/36 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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