METHOD OF PROMOTING CERVICAL AND VAGINAL SECRETIONS

摘要

The present invention provides a method of stimulating cervical and vaginal secretions in a mammal by treatment with P2Y2, and/or P2Y4 purinergic recept or agonists. Treatment of vaginal dryness associated with menopause, chemotherapy, and various disease states as well as the treatment of vulvar pain is discussed. Suitable purinergic receptor agonists include nucleotide triphosphates such as uridine 5-triphosphate, cytidine 5'-triphosphate and adenosine 5'-triphosphate; dinucleotide polyphosphates such as P1, P4- di(uridine-5') tetraphosphate; and their analogs. These purinergic receptor agonists are useful in stimulating cervical and vaginal secretions and treating vaginal dryness in mammals.