PROPANOIC ACID DERIVATIVES AS INTEGRIN INHIBITORS

摘要

Propanoic acid derivatives of formula (1) are described: Ar-X<1>-Ar<1>-Z-R in which Ar is a nitrogen base containing group; X<1> is linker atom or group; Ar<1> is an optionally substituted 5- or 6-membered nitrogen-containing aromatic or non-aromatic monocycle; Z is a group -CH(R<13>)CH2- [in which R<13> is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group], -C(R<12a>)(R<13>)-CH(R<12b>)- [in which R<12a> and R<12b> together with the carbon atoms to which they are attached form a C3-7cycloalkyl group] or C(R<13>)=CH-; R is a carboxylic acid (-CO2H) or a derivative or biostere thereof; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of alpha V integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.