发明名称 |
NEURON STIMULATION BY RIBAVIRIN, AND ANALOGS THEREOF |
摘要 |
The present invention is directed to compositions comprising 1-( beta -D-ribofuranosyl)-1H-1,2,4-triazole compounds and either endogenous or exogenous neurotrophic factors. Methods of using such compounds and compositions are also provided. In one aspect, the invention provides methods of using invention compositions and compounds to enhance neurite outgrowth, neuronal survival and neuronal proliferation in mammalian cells. In a preferred embodiment, a 1-( beta -D-ribofuranosyl)-1H-1,2,4-triazole compound is infused directly to a desired situs. In a more preferred embodiment the 1-( beta -D-ribofuranosyl)-1H-1,2,4-triazole compound is administered orally. In another aspect, the invention provides methods of treating a neurological disease in a mammal subject. In a further aspect, the invention provides methods of treating neuronal trauma in a mammal subject. |
申请公布号 |
WO0030656(A1) |
申请公布日期 |
2000.06.02 |
申请号 |
WO1999US27475 |
申请日期 |
1999.11.19 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;GUILLEMIN, ROGER, C., L.;GAGE, FRED, HARRISON;RAY, JASODHARA |
发明人 |
GUILLEMIN, ROGER, C., L.;GAGE, FRED, HARRISON;RAY, JASODHARA |
分类号 |
A61K38/18;C07H5/06;C07H19/056 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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