| 摘要 |
Process for the preparation of etodolac, comprising the following steps: a) reacting 7-ethyl-tryptophol of formula (II) with methyl 3-oxo-pentanoate of formula (III) thereby obtaining methyl 1,8-diethyl-1,3,4,9-tetrahydropyrano [3,4-bis] indole-1-acetate of formula (IV) in an apolar solvent; b) hydrolyzing the compound of formula (IV) to etodolac (I), wherein step (a) is carried out at a temperatures of between -20 DEG C. and +50 DEG C. in the presence of a concentrated mineral acid, the molar ratio of the inorganic acid to 7-ethyl-tryptophol being comprised between 0.5 and 5.
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