| 发明名称 |
Compounds derived from an amine nucleus that are inhibitors of impdh enzyme |
| 摘要 |
The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases. |
| 申请公布号 |
AU1131500(A) |
申请公布日期 |
2000.05.22 |
| 申请号 |
AU20000011315 |
申请日期 |
1999.10.22 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHUNJIAN LIU;T. G. MURALI DHAR;HENRY H. GU;EDWIN J. IWANOWICZ;KATERINA LEFTHERIS;WILLIAM JOHN PITTS |
| 分类号 |
A61K31/4196;A61K31/421;A61K31/422;A61K31/4245;A61K31/433;A61K31/4439;A61K31/454;A61K31/496;A61K31/513;A61K31/53;A61K31/5377;A61P29/00;A61P31/12;A61P35/00;A61P37/02;A61P43/00;C07D263/32;C07D263/48;C07D403/12;C07D413/12;C07D413/14;C07D417/12;C07D521/00 |
主分类号 |
A61K31/4196 |
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